PARA-CLINICAL EVALUATION OF TAXANE SIDE EFFECTS ON AUDITORY SYSTEM (PTA -TRESHOLD)

Ototoxicity is one of the major causes of hearing loss and balance system disorders.Taxans are new of anti-neoplastic agents chemotherapy with these agents include Paclitaxel and Docetaxel. In this study we have been evaluated ototoxicity of these drugs to adjust dose if necessary to avoide their complications.This is a study of 103 known cases of breast and ovarian cancer with mean age 45 ± 2.3 years during may 2004 to jun 2006 (20 months) in Ahwaz That were treated with Taxans (in a 20 months period).The first evaluation of hear ing (with PTA) was performed before initiation of treatment and the second was performed at the middle of treatment period and the last one at the end of treatment. Nausea and vomiting was the most common side effect of these drugs in this study. We did not any significant side effects of taxanes on audiovestibular system. There is few information about ototoxicity effect of Taxanes in the other studies, and we did not find any significant effect on Auditory system in the PTA standard ( 0/5 - 8 KHZ).