Author/Authors :
Syukri, Maimun Department of Internal Medicine - School of Medicine - Syiah Kuala University, Banda Aceh, Indonesia , Imran, Imran Medical Research Unit - School of Medicine - Syiah Kuala University, Banda Aceh, Indonesia , Harapan, Harapan Medical Research Unit - School of Medicine - Syiah Kuala University, Banda Aceh, Indonesia , Sja’bani, Mochammad Department of Internal Medicine - Faculty of Medicine - Gadjah Mada University, Yogyakarta, Indonesia , Astuti, Indwiani Department of Pharmacology - Faculty of Medicine - Gadjah Mada University, Yogyakarta, Indonesia , Soesatyo, Marsetyawan HNE Department of Histology and Cell Biology - Faculty of Medicine - Gadjah Mada University, Yogyakarta, Indonesia
Abstract :
Background: C3 complement plays a pivotal role in the complement cascade, subserves several critical functions in human immune response and enhancing bacterial killing and its levels correlate with infectious diseases. However, the association of C3 with recurrent urinary tract infection (UTI) is still debatable. Aim: The aim of this study was to assess the correlation of serum C3 levels and recurrent UTI among young women. Materials and methods: Thirty-four recurrent UTI patients whose diagnosed based on Society of Obstetricians and Gynecologists of Canada and European Association of Urology criteria and 34 healthy young women, aged 15–50 years old, were included in this study. Risk factors and clinical manifestations were evaluated and serum C3 levels were measured by ELISA. Correlations of risk factors, clinical manifestation and C3 levels with recurrent UTI were analyzed with chi-square test and Fisher’s exact test or t-test as appropriate with data.
Keywords :
Urinary tract infection , Recurrent UTI , C3 , Complement , Host immunity
