Abstract :
This study was accomplished in Medical University – Pathologoanatomic Department of the Clinic of Thoracic Surgery. Sofia,. Bulgarian, were collected the paraffin blocks, by using new technology Tissue microarrays (TMA) and Fluorescence In Situ Hybridization (FISH)) on different type of ovarian tumors . The method of FISH applied on TMA with HER1 and HER2 specific probes proved itself as the most commonly used and valuable analysis for routine HER2 status detection and copy number changes . The results showed in out of all 603 ovarian carcinomas examined, the number of successfully hybridized for HER2 oncogene is 303 (50.2%) 192 of them are malignancies tumors (179 epithelial and 13 non epithelial ) ,18 low malignant ovarian tumors( just epithelial ), 93 – Benign ovarian tumors(77 epithelial and 16 non epithelial ) . We established HER2 amplification in malignancies tumors only 20 (10.41%) ,19 (10.61%) epithelial and in 1 (7.69%) non epithelial )
