Influence of the different doses of sodium fluoride on the rabbit exocrine pancreas .Histo – pathological study

The present study was carried out on the (18) male rabbits, to identify the effect of different concentration of sodium fluoride on histological structure of rabbits exocrine pancreas. The experimental animals were randomly divided into three groups, control group, the first treated group admimenstreted(200)ppm sodium fluoride daily with drinking water for six week period. The second treated group adimenstered (300) ppm sodium daily in drinking water with same experiment period, each group was included six male rabbits The moderate histo-pathological alterations was occurred in the rabbits exocrine pancreas, represent by degenerative changes in the pyramidal cells of acini and lost of zymogenic granules in some acinar cells while the sever histo-pathological changes in the histological structure units of the rabbits exocrine pancreas in the second treated group involved sever degeneration,necrosis and a trophy from other hand enlargement of interstitial and intralobular ducts