Title of article
Evaluation of Hydroxyethyldiclofenac Intestinal Absorption in Rats
Author/Authors
Idkaidek, Nasir M. Jordan University of Science and Technology - College of Pharmacy, Jordan , Jilani, Jamal A. Jordan University of Science and Technology - College of Pharmacy, Jordan , Mansi, Iman A. Jordan University of Science and Technology - College of Pharmacy, Jordan
From page
158
To page
163
Abstract
The mechanism of intestinal mucosal transport of hydroxyethyldiclofenac, an ester prodrug ofdiclofenac, in rats was investigated. Another objective was to identify optimal sites of absorptionand then to identify the gastrointestinal toxicity. Both the parent drug and the prodrug were foundto be passively absorbed from rat jejunum. The permeability coefficients of the prodrug weretenfold higher (p 0.05) than that of the parent drug in the three regions of rat small intestine(duodenum, jejunum and ileum). In addition, the prodrug was found to be less ulcerogenic (p 0.05) after single and chronic dose than the parent drug. In conclusion, the prodrug was found a good candidate for oral delivery as compared to parent compound.
Keywords
Diclofenac sodium , prodrug , permeability , ulcerogenicity index , intestinal absorption
Journal title
Saudi Pharmaceutical Journal(SPJ)
Journal title
Saudi Pharmaceutical Journal(SPJ)
Record number
2684337
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