Author/Authors :
Abu Sheikha, Ghassan M. Al-Zaytoonah Private University of Jordan - Department of Pharmacy, Amman , Bkhaitan, Majdi M. Al-Zaytoonah Private University of Jordan - Department of Pharmacy, Jordan , Al-Hourani, Rami A. Jordan University - Department of Pharmaceutical Chemistry and Pharmacognosy, Amman , Qaisi, Ali M. Jordan University - Department of Pharmaceutical chemistry and Pharmacognosy, Amman , Loddo, Roberta Universita` di Cagliari - Dipartimento di Biologia Sperimentale, Italy , La Colla, Paolo Universita` di Cagliari - Dipartimento di Biologia Sperimentale, Italy
Abstract :
Bis(pivaloyloxymethyl) ester derivative of 9-{((Phosphonomethyl)aziridin-1-yl)methyl}adenine, (bis POM)PMAMA) (1), is an analogue of adefovir dipivoxil and tenofovir disoproxil. Compounds 2, 3, and 4 were prepared in similar way to 1.They were tested in vitro against a wide range of viruses, in articularly against HIV-1 and hepatitis viruses.
