Title of article
SYNTHESIS AND BIOLOGICAL EVALUATION OF CERTAIN 2H-PYRAN-2- ONES AND SOME DERIVED 1H-PYRIDIN-2-ONE ANALOGS AS ANTIMICROBIAL AGENTSa
Author/Authors
Faidallah, Hassan M. King Abdulaziz University - Faculty of Medicine - Department of Medicinal Chemistry, Saudi Arabia , AI-Saadi, Mohammed S. King Abdulaziz University - Faculty of Medicine - Department of Medicinal Chemistry, Saudi Arabia , Rostom, Sherif A. F. King Abdul-Aziz University - Faculty of Medicine - Division of Medicinal Chemistry, Jeddah
From page
33
To page
42
Abstract
Pyran-2-one and pyridine-2-one analogs are known to be biological versatile compounds possessing variety of pharmacological activities. Some 4-(4-nitrophenyl)-5,6-diphenyl-pyran-2- ones and their lH-pyridin-2-one analogs were synthesized and evaluated for their in vitro antimicrobial activities. The chemistry of the reactions employed for the synthesis of the intermediates and target compounds was discussed. The results revealed that some compounds exhibited promising antibacterial and antifungal activities. Compound 8; 1-hydroxy-4-(4- nitrophenyl)-5,6-diphenyl-lH-pyridin-2-one; showed the most potent broad spectrum antimicrobial activity. l-Methyl-4-(4-nitrophenyl)-5,6-diphenyl-lH-pyridin-2-thione 12; was able to exert weak growth inhibitory effect against the Mycobacterium tuberculosis.
Keywords
Pyran , 2 , ones , pyridin , 2 , ones , antibacterials , antifungals , antimycobacterials
Journal title
Saudi Pharmaceutical Journal(SPJ)
Journal title
Saudi Pharmaceutical Journal(SPJ)
Record number
2684364
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