Title of article :
SYNTHESIS AND ANTITUMOR ACTIVITY OF SOME 5H-PYRROLIZINE, PYRIMIDO [5,4-a] PYRROLIZINE PYMMIDO[4,5-b]PYRROLIZINE DERIVATIVES
Author/Authors :
EI-Moghazy Aly, Samir M. Cairo University - Faculty of Pharmacy - Pharmaceutical Chemistry Department, Egypt , Azim Mohamed, Mohamed A. Cairo University - Faculty of Pharmacy - Pharmaceutical Chemistry Department, Egypt , Farag, Awatif. EI-S. Cairo University - Faculty of Pharmacy - Pharmaceutical Chemistry Department, Egypt , Gouda, Ahmed. M. Beni-Suef University - Faculty of Phannacy - Pharmaceutical Chemistry Department, Egypt
Abstract :
Seven new series of condensed pyrrolizine derivatives of anticipated antitumor activity have been synthesized. Comprises ethyl-1-cyano-3-phenylcarbamoyl-6,7-dihydro-5H- pyirolizin-2-y1-carbamate, 2.4-dioxo-1H-pvrimido[4.5-b]pyrrolizine-9-carbonitnle. 1- cyano-2-(3-substituted ureido)-3N-phenyl-6,7-dihydro-pyrrolizine-3-carboxamide, 3- (alkyl / phenyl)-4-imino-2-oxo-9N-phenyl-2,3,4,5,6,7-hexahydro-1H-pyrimido [5,4- a]pyrrolizine-9-carboxamide , 4-amino-3-(alkyl / phenyl)-2-oxo-2,3,4,5,6,7-hexahydro- 1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide, of 2-amino-3N-phenyl-6,7-dihydro- 5H-pyirohzine-1,3-dicarboxamide and 4-oxo-9N-phenyl-4, 5,6,7-tetrahydro-3H- pyrimido[5,4-a]pyrrohzin-9-carboxamide derivatives. Eleven were screened for their in vitro antitumor activity and ten compounds proved to possess moderate to weak activities.
Keywords :
Pyrrolizine , pyrimido[4.5 , b]pyrrolizine. pyrimido[5 , 4 , a] , pyrrolizine , anticancer , probit analysis
Journal title :
Saudi Pharmaceutical Journal(SPJ)
Journal title :
Saudi Pharmaceutical Journal(SPJ)
