Illustration of anti-rheumatic mechanism of rheumavedic capsule

The present study was taken up to illustrate the mechanism of anti-rheumatic activity of ‘Rheumavedic capsule’, a polyherbal formulation of Vedic-bio Labs, Bangalore, in adjuvant induced arthritic rats. Anti-inflammatory mechanism is illustrated using phlogistic agents induced paw edema in rats. Analgesic mechanism is illustrated using Eddy’s hot plate and acetic acid (0.6%v/v) induced writhing in mice. Histopathology of knee joint was studied. Rheumavedic showed inhibition of inflammation mediated through Histamine, 5-Hydroxy trypt- amine, and Bradykinin. Rheumavedic showed protection in both acetic acid and Eddy’s hot plate induced pain. Histopathology of knee joint of rat pre-treated with rheumavedic showed significant reduction in the mononuclear infiltration, pannus formation and adhesion molecules. The anti-rheumatic mechanism of rheumavedic is due to; inhibition of inflammatory mediators i.e., Histamine, 5-Hydroxy tryptamine and Bradykinin., protection against prostaglandins mediated pain, by inhibiting cyclo-oxygenase synthesis and reduction in pannus formation, by inhibiting mononuclear infiltration.