Author/Authors :
Okçu, Kemal Murat Departments of Oral and Maxillofacial Surgery Anatomy - Gülhane Military Medical School, Ankara , Doğan, Necdet Departments of Oral and Maxillofacial Surgery Anatomy - Gülhane Military Medical School, Ankara , Şençimen, Metin Departments of Oral and Maxillofacial Surgery Anatomy - Gülhane Military Medical School, Ankara , Korkmaz, Cem IVF Laboratories - Gülhane Military Medical Academy, Ankara, Turkey , Altuğ, Hasan Ayberk Department of Orthodontics - Etimesgut Military Hospital, all in Ankara , İde, Tayfun Departments of Laboratory Animal Research - Gülhane Military Medical School, Ankara , Akyol, Mesut Gülhane Askeri Tıp Akademisi - Biyoistatistik Bilim Dalı, Ankara
Abstract :
Objectives: The purpose of this study was to test the hypothesis that the hemostatic agent (FastAct) exerts favourable effect on wound healing and tissue repair alone and along with prilocaine hydrochloride in vivo. Wound healing process is a complex procedure that starts with bleeding and hemostasis. Comprising of bovine factor proteins II, VII, IX and X, FastAct is used as a catalyst in the clot formation process to activate factors II, V, VIII and XIII. Materials and Methods: The study was performed on 21 Wistar male rats. Cutaneous incisions at the length of 4 cm. were made on the dorsal side of all animals. In seven, FastAct was applied alone between the wound edges and, in the other seven, FastAct was applied along with prilocaine. The wounds were sutured by resorbable suture material. Results: The specimens were obtained on the seventh day. Wound breaking strength test was performed before histological examination. In the FastAct group the epi-thelialization and the closure of the wound edge were better than the other groups. The results of the break-ing strength test showed that the results were best in FastAct group. Conclusion: It’s concluded that FastAct accomplished hemostasis, facilitated wound healing in accordance with natural processes.
