Title of article
A Destroyer Immunologic Cause in Small Cell Lung Carcinoma: Ectopic Cushing’s Syndrome
Author/Authors
Çiçin, İrfan Trakya Üniversitesi Tıp Fakültesi - İç Hastalıkları Anabilim Dalı, Edirne , Karagöl, Hakan Trakya Üniversitesi Tıp Fakültesi - İç Hastalıkları Anabilim Dalı, Edirne , Uzunoğlu, Sernaz Departments of Medical Oncology - Medical Faculty of Trakya University, Edirne , Ermantaş, Nilay Departments of Medical Oncology - Medical Faculty of Trakya University, Edirne , Usta, Ufuk Departments of Pathology - Medical Faculty of Trakya University, Edirne , Temizöz, Osman Departments of Radiology Medical Faculty of Trakya University, Edirne
Pages
3
From page
312
To page
314
Abstract
Ectopic secretion of adrenocorticotropic hormone(ACTH) related Cushing s syndrome (CS) is morefrequently observed than many other paraneoplasticsyndromes in patients with small cell lung cancer.Suppression of the cellular immune system in thesepatients is severe problem for both patients and physi-cians. In addition, the chemotherapy has been causedto severity and higher rate of hematological toxicity.We present a case of small cell lung cancer having avery poor prognosis, with a compressed humoral andcellular immune system due to an ectopic secretion ofACTH related CS. We report a rare case of combinedimmunosuppression in a case with small cell lung can-cer in this paper. In addition, in the light of this specialcase and literature, we suggest treatment strategiesfor small cell lung cancer patients with CS.
Keywords
Cushing s syndrome , small cell lung cancer , immunosuppression
Journal title
Balkan Medical Journal
Serial Year
2010
Journal title
Balkan Medical Journal
Record number
2685685
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