Canlı Donörden Böbrek Transplantasyonu Yapılan Hastalarda Minör HA-1 Dağılımı

Objectives: The importance of the Human LeukocyteAntigens (HLA) matching is well known in renal transplanta-tion that is one of the best treatment options for end-stagesolid organ deficiency. Human Leukocyte Antigens match-ing between recipient and donor has an influence on graftsurvey after the renal transplantation. However alloge-neic renal transplants between HLA identical siblings mightbe ended with rejection. Minor histocompatibility antigen(mHag) HA-1 is a nine-amino acid peptide encoded by adiallelic gene on human chromosome 19. mHags havelow polymorphisms. Minor histocompatibility antigens arelikely to function as potantial risks for graft rejection of HLA-matched solid organ transplantation. In our study, we aimedto investigate the effect of minor HA-1 mismatch on kidneytransplant survey. Patients and Methods: We examined the HA-1 locus in living donor renal transplant patients (n=59) and their donors. We used PCR-SSP for HA-1 typing. Results: The frequencies of the three possible genotypesHH, RR, HR were 17%, 25% and 58%, respectively, in recipi-ents. No significant correlation was established between the occurrence of rejection/rejection episodes and HA-1matching (p=0.73, Or=1.44, Confidence intervals= 0.36-5.74;Fischer’s Exact Test). In addition, no significant carrelationwas established between CAN (chronic allograft nephropa-thy) and mHA-1 matching (p=0.61, Or=2.89, Confidenceintervals=0.28-29.57; Fischer’s Exact Test). Conclusion: We could not find relation between graft survey and HA-1 match/mismatch in living donor kidney transplantation.