Author/Authors :
Terzi, Alpaslan Harran Üniversitesi Tıp Fakültesi - Genel Cerrahi Anabilim Dalı, Şanlıurfa , Kaya, Murat Harran Üniversitesi Tıp Fakültesi - Genel Cerrahi Anabilim Dalı, Şanlıurfa , Çoban, Sacit Gaziantep Üniversitesi Tıp Fakültesi - Genel Cerrahi Anabilim Dalı, Gaziantep , Yıldız, Fahrettin Department of General Surgery - Medical Faculty of Harran University, Şanlıurfa , Abdullah, Taşkın Harran Üniversitesi Tıp Fakültesi - Klinik Biyokimya Anabilim Dalı, Şanlıurfa
Abstract :
Objective: The aim of our study was to investigate the oxidative and antioxidative status of plasma and plasma prolidase enzyme activity on gallstone disease. Material and Methods: The study group included 35 patient with gallstone disease and 30 healthy volun- teers as control subjects. Plasma prolidase activity and oxidative-antioxidative parameters were measured. Antioxidative status of plasma was evaluated by mea- suring total antioxidant capacity. To determine oxidative status; total oxidant status and oxidative stress index were deermied. Results: Total antioxidant capacity levels of plasma were lower in the patients with gallstone disease than in controls (p 0.001). In contrast, total oxidant status lev- els and oxidative stress index values were higher in the patients than in controls (p 0.05 and p 0.001, respec- tively). Beside these, plasma prolidase activity was sig- nificantly lower in the patients than controls (p 0.001). Conclusions: The present results indicated that the oxi- dant parameters increased and antioxidant parameters decreased in patients with gallstones, and that these patients were exposed to oxidative stress.
