Author/Authors :
Ayna, Tülay Kılıçaslan Department of Medical Biology - Faculty of Medicine - İstanbul University, İstanbul, Turkey , Gürkan, Hakan Department of Medical Biology - Faculty of Medicine - İstanbul University, İstanbul, Turkey , Tozkır, Hilmi İstanbul Üniversitesi İstanbul Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, İstanbul, Türkiye , Çiftçi, Hayriye Şentürk İstanbul Üniversitesi İstanbul Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, İstanbul, Türkiye , Gürtekin, Mehmet İstanbul Üniversitesi İstanbul Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, İstanbul, Türkiye , Tekgündüz, Emre Department of Hematology - Haydarpaşa Training Hospital - Gülhane Military Medical School, İstanbul , Algüneş, Çetin Trakya Üniversitesi Tıp Fakültesi Tıbbi Biyoloji Anabilim Dalı, Edirne , Çarin, Mahmut Departments of Gastroenterohepatology - İstanbul Medical Faculty of İstanbul University, İstanbul
Abstract :
Graft Versus Host Disease (GVHD) remains a major cause of morbidity and mortality in allogeneic stem cell transplantation (SCT). The MLC assay has been generally accepted as a standard test for determining HLA-D region compatibility. In this study, the MLC test has been carried out on the re- lated recipient-donor couple who were prepared for allogeneic SCT and were found to be matched for HLA-A, -B, -Cw, DR, DQ but not for -DP. The result of the MLC test was positive. We observed that HLA-DP mis- match was responsible for the increased proliferation values in MLC test.
Keywords :
Mixed lymphocyte culture , HLA , DP , stem cell transplantation
