Overin Yüzey Epitelyal-Stromal Tümörlerinde Tp53 Ekspresyonu ve Ki-67 Proliferasyon İndeksi ve Histopatolojik Prognostik Parametrelerle İlişkileri

Objective: To investigate TP53 and Ki-67 expressions in malignant, bor- derline and benign epithelial ovarian tumors; correlate results with his- topathological parameters; compare TP53 and Ki-67 expressions and discuss ovarian carcinogenesis. Material and Methods: Standard immunohistochemistry was performed in 100 malignant, 27 borderline and 31 benign tumors and 42 non-tumor- al ovarian epithelia. Results: TP53 overexpression was higher in malignant (61.0%) than in borderline tumors (40.7%); in malignant cases above 50 years-of-age, with high grade and in undifferentiated and serous subtypes. Carcino- mas with solid architecture in serous, high mitosis in non-serous and high pleomorphism in both subtypes; lymph node involvement, and advanced stage also showed higher expressions of TP53 (p 0.05). The mean Ki-67 index was 41.3% in malignant and 17.2% in borderline tumors. Ki-67 index tended to increase with increasing grade, and decrease with lymph node involvement. The coexpression of proteins according to grade, lymph node involvement and stage in different subtypes, showed significant dif- ferences and correlations. Conclusion: Our findings support the role of TP53 overexpression in de- velopment of “borderline” and malignant epithelial ovarian tumors. The degree of TP53 expression differed in terms of histopathological parame- ters; and was correlated with Ki-67 index. Especially in early stages, these biological factors could provide additional information to stratify patients for case specific therapies.