Electrochemical Sensor Based on Nanocomposite of Multi-Walled Carbon Nano-Tubes (MWCNTs)/TiO2/Carbon Ionic Liquid Electrode Analysis of Acetaminophen in Pharmaceutical Formulations

This study aimed at preparing a Carbon Ionic Liquid Electrode (CILE) modified with a new composite of Multi-Walled Carbon Nano-Tubes (MWCNTs) and TiO2 nanoparticles for AC determination. The proposed electrode was made of a Carbon Paste Electrode (CPE) modified with TiO2 Nano-Particle (NP)-decorated MWCNTs and a binder of IL 1-hexyl-pyridinium hexafluorophosphate (HPFP) (MWCNT/TiO2/CILE). The nanocomposite structure characterization was done via X-ray Energy-Dispersive Spectroscopy (EDS) and Field-Emission Scanning Electron Microscopy (FESEM). The electrochemical behavior of Ac was investigated via the Cyclic Voltammetry (CV) technique at the MWCNT/TiO2/CILE. The MWCNT/TiO2/CILE was applied for Ac determination by Square-Wave Voltammetry (SWV) technique in real samples. The excellent electrocatalytic activity of the proposed nanocomposite leading to Ac electrochemical oxidation in phosphate buffer solution (pH 6.0) was evidenced. The results of Square-Wave Voltammetry (SWV) revealed a wide linear range of 0.01-30 µM and the detection limits of 0.003 µM for the modified electrode under optimal conditions. This electrode was successfully employed to detect Ac concentrations in plasma and tablet samples with good repeatability and reproducibility.