The Effects of Caffeic Acid Phenethyl Ester and Ellagic Acid on Oxidative Stress Created by Acute Malathion Toxicity in Rat

The aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE) and ellagic acid (EA) on acitivities of malondialdehyde (MDA), reduced glutathione (GSH) and nitric oxide (NO) in rat lung, liver and kidney tissues in acute malathion (MAL) toxicity. A total of 36 mature female Sprague Dawley rats were randomly divided into 6 groups of 6 including control, CAPE, EA, MAL, MAL+CAPE, MAL+EA. Reduced GSH, MDA and NO levels in lung, liver and kidney tissues were measured colormetrically by spectrophotometer. When the unmedicated control group was compared with the CAPE and EA groups, there was no statistically significant difference between the groups in terms of GSH, MDA and NO acitivities. It was determined that MDA levels in liver tissue were significantly increased by MAL, but CAPE significantly reduced the MDA levels by blocking the toxic effect of MAL. Also, it was observed that the reduced GSH levels in the liver tissues of the groups given MAL were reduced, but CAPE and EA increased reduced GSH levels. The NO levels of the groups given MAL were significantly increased dependent on the severe tissue damage created by MAL, but CAPE and EA reduced those levels. As a result, it was concluded that CAPE and EA, which showed similar effects to each other, could be used for protection against the severe oxidative stress and damage tissue caused by acute MAL poisining.