The Effects of Propofol and Isoflurane Anaesthesia on Oxidative Stress in Angora Goats

The aim of this investigation was to determine the effect of propofol and isoflurane on blood malondialdehide and antioxidant levels in goats. The study was performed on seven clinically healthy, adult, female Angora goats weighting between 33.8-49 kg. Anesthesia was induced with 6.56±1.42 mg/kg propofol as a bolus dose intravenously and maintained with %1-3 isoflurane in 100% oxygen for an hour period. Blood samples were collected before and after propofol administration and 15, 30, 60, 120 min and 24 h after isoflorane administration. Malondialdehyde (MDA), vitamin A and carotene levels were examined in plasma, while superoxide dismutase (SOD) and catalase (CAT) activities were determined in erythrocytes. In general, there was no significant difference recorded on MDA and vitamin A levels, and SOD and CAT activities before and after propofol and isoflorane administration except for carotene. Beta carotene levels were significantly increased after propofol administration (P 0.05). In conclusion, it was determined that propofol and isoflurane anaesthesia had no adverse effect on blood MDA and antioxidant parameters in Angora goats.