First Detection of Hypomyelination Associated with Bovine Viral Diarrhoea Virus in an Aborted Calf in Gumushane Region

In this study, hydranencephaly and mild cerebellar hypoplasia were reported macroscopically, microscopically and immunohistochemically in an aborted Holstein Friesian calf. A relationship between Bovine Viral Diarrhoea Virus (BVDV) infection and histopathology associated with the central nervous system (CNS) lesions were demonstrated. In the histopathology, perivascular haemorrhage, oedema, neuronal necrosis and degeneration were observed in the CNS. BVDV positive immunoreaction was detected in neurons, glial and endothelial cells of CNS by immunohistochemical examination. As far as the authors are concerned, this is the first report of BVDV present in an aborted Holstein Friesian Calf in Gumushane region. This finding may have important implications for the epidemiology and control of BVDV infection in the Gumushane region.