Author/Authors :
Abtlulrakman, Loay K. Al-mustanseria University - College of pharmacy, Iraq , Al-Abachi, Anas M. University of Almustanseria - College Pharmacy, Iraq , Al-Qaissy, Mayada H. University of Al-mustanseria - College Pharmacy, Iraq
Abstract :
A simple, accurate and sensitive spectrophotometric method for the determination of promethazine.! IC1 has been developed. The method is based on the oxidative coupling reaction of promethazine.! ICJ with P-aminobenzoic aeid and in the presence of N-bromosuccinimide to form an intense bluish-green water soluble dye that is stable and has a maximum absorption at 600nm.A graph of absorbance versus concentration shows that Beer s law is obeyed over the concentration range of50-750 (.ig of promethazine.I ICl in a final volume of 25ml.(i-e 2-30ppm) with a molar absorptivity of 1.0*104 L m o f W , a recovery% of 98.10-101.00 and a relative standard deviation of better than 1.2% depending on the concentration .The optimum conditions for full colour development are described and the proposed method was applied satisfactorily to the pharmaceutical dosage forms
