Author/Authors :
Sulaiman, Ghassan M. university of Technology - Biochemicl Technology Division - Applied Sciences Department, Iraq , Fazaa, Nadheer A. university of Baghdad - College of Science for Women - Department of Biology, Iraq , Abdul-Wahed, Hamssa E. university of Baghdad - College of Science for Women - Department of Biology, Iraq
Abstract :
r orty- s ix patients with asthma were tested for the serum levels of total sialic acid (TS/), Immunoglobulins (lg/, IgE, IgG, and TgM) and leukocyte counts (total mid differential). The results revealed a significant increased (P 0.0001) level ol TS/ in the scra or· asthmatic patients ( 120.8] :L: 6.50 r~~.; 69.80 :I: 4.J6; mg/di .) ;rnd such increase wns associalcd wilh signi fi c;int i11crc;1scs in the levels or lg/(248.73±56.45 vs 64.70± 14.30;mg/dL), lgE (1 483 .16~1:484.97 vs 30.33±8.21 ;IU /mL), IgG ( 1273.73± 139.37 vs 572.60±51.J l ;mg/dL) and IgM (187.38±22.60 vs38. 18±5.2 1; mg/dL). The data al so shov.. 1 ed non significant elevation in neutrophil s, lymphocytes and monoeytes. However, eosinophils were an exception mid a significant increase (P 0.0001) was observed in the patients. In conclus ion, TS/ could be a ri sk foctor and a believe may be born that a modification o f sialic acid residues might intcrrcrc with cel l - cc!l recogn ition and interactions, which play a crucial role during immune response
