Title of article :
Effect of Methotrexate on the Liver Enzymes and Lipid Profile in Adult Female Albino Mice
Author/Authors :
Alwachi, Sabah N. Universityof Baghdad - College of Science - Department of Biology, Iraq , Alsaadi, Yasmin L. Universityof Baghdad - College of Science - Department of Biology, Iraq
Abstract :
Methotrexate (MTX) was used for treatment of malignancies and now is widely used in treatment of rheumatoid arthritis. In this research the evaluation of the effects of MTX on some liver enzymes and lipid profile was studied. Twenty four adult female mice divided into three groups (8 mice each). The first two groups were treated with MTX while the third group was used as a control. MTX was intraperitoneally given at 50 μg/ml and 75 μg/ml to the first and second groups respectively for 35 days ,whereas the control group was intraperitoneally injected with normal saline. The results showed a significant (p 0.05) increase in serum levels of glutamic oxaloacetate transaminase (GOT) , glutamic pyruric transaminase (GPT), Alkaline phosphatase (ALP) , total cholesterol and triglyceride (TG), however high density lipoprotein (HDL) showed a significant (p 0.05) decrease in mice treated by MTX when compared with control group
Keywords :
(MTX) Methotrexate , (GOT) glutamic oxaloacetate Transaminase , (GPT)Glutamic Pyruric Transaminase , (ALP) alkaline phosphatase , (TG) triglyceride , (HDL) high density lipoprotein , (LDL , c) low density lipoprotein , cholesterol
Journal title :
Baghdad Science Journal
Journal title :
Baghdad Science Journal
