Author/Authors :
Azizi, Gholamreza alborz university of medical sciences - Imam Hassan Mojtaba Hospital - Department of Laboratory Medicine, ايران , Azizi, Gholamreza tehran university of medical sciences tums - Children’s Medical Center, Research Center for Immunodeficiencies, تهران, ايران , Navabi, Shadi S. tehran university of medical sciences tums - School of Public Health - Department of Immunology, تهران, ايران , Al-Shukaili, Ahmed Research Council Oman - Health Social Services Sector,, Oman , Seyedzadeh, H. tehran university of medical sciences tums - School of Public Health - Department of Immunology, تهران, ايران , Yazdani, Reza tehran university of medical sciences tums - School of Public Health, Children’s Medical Center, Research Center for Immunodeficiencies, تهران, ايران , Yazdani, Reza isfahan university of medical sciences - Faculty of Medicine - Department of Immunology, ايران , Mirshafiey, Abbas tehran university of medical sciences tums - School of Public Health - Department of Immunology, تهران, ايران
Abstract :
Alzheimer’s disease (AD), a neurodegenerative disorder associated with advanced age, is the mostcommon cause of dementia globally. AD is characterised by cognitive dysfunction, deposition of amyloid plaques, neurofibrillary tangles and neuro-inflammation. Inflammation of the brain is a key pathological hallmark of AD. Thus, clinical and immunopathological evidence of AD could be potentially supported by inflammatory mediators, including cytokines, chemokines, the complement system, acute phase proteins and oxidative mediators. In particular, oxidative mediators may actively contribute to the progression of AD and on-going inflammation in the brain. This review provides an overview of the functions and activities of inflammatory mediators in AD. An improved understanding of inflammatory processes and their role in AD is needed to improve therapeutic research aims in the field of AD and similar diseases.
Keywords :
Alzheimer’s Disease , Inflammation Mediators , Cytokines , Chemokines , Complement System Proteins , Acute Phase Proteins
