Improvement in adherence to surgical antimicrobial prophylaxis guidelines after implementation of a multidisciplinary quality improvement project

Objectives: This study aimed to show the impact of a multidisciplinary quality improvement project on adherence to antimicrobial prophylaxis guidelines in oncological surgery. Methods: This pre- and post-intervention prospective observational study was carried out at the King Hussein Cancer Centre (KHCC) in Amman,Jordan,between August 2009 and February 2012. The quality improvement project consisted of revising the institutional guidelines for surgical antimicrobial prophylaxis,assigning a clinical pharmacist to the surgical department,establishing an operating room satellite pharmacy and providing education regarding the appropriate utilisation of antibiotics. The medical records of adult cancer patients who underwent surgery were evaluated one month before and one month after the project was implemented to assess adherence to the guidelines with regards to antibiotics prescribed,drug doses and timing and treatment duration. Results: A total of 70 patients were evaluated before and 97 patients were evaluated after the intervention,of which 57 (81.4%) and 95 (97.9%) patients received antibiotics,respectively. In comparing the pre- and post-intervention groups,an improvement was observed in the proportion of patients who received antibiotics at the appropriate time (n = 12 versus n = 79; 21.1% versus 83.2%; P 0.01),for the appropriate duration of time (n = 22 versus n = 94; 38.6% versus 99.0%; P 0.01) and in the appropriate dose (n = 9 versus n = 87; 56.3% versus 98.9%; P 0.01). Conclusion: Adherence to the antimicrobial prophylaxis guidelines at KHCC improved significantly after the implementation of a quality improvement project.