Author/Authors :
Hosseini, Mostafa tehran university of medical sciences tums - School of Public Health - Department of Epidemiology and Biostatistics, تهران, ايران , Seyed Alinaghi, Seyed Ahmad tehran university of medical sciences tums - Iranian Research Center for HIV/AIDS (IRCHA), تهران, ايران , Adimi Naghan, Parisa shahid beheshti university of medical sciences - NRITLD, Masih Daneshvari Hospital - Department of Pulmonary Medicine, تهران, ايران , Karimi, Shirin shahid beheshti university of medical sciences - NRITLD, Masih Daneshvari Hospital - Department of Clinical Anatomical Pathology, تهران, ايران , Bahadori, Moslem shahid beheshti university of medical sciences - NRITLD, Masih Daneshvari Hospital - Department of Clinical Anatomical Pathology, تهران, ايران , Khodadad, Kian shahid beheshti university of medical sciences - NRITLD, Masih Daneshvari Hospital - Chronic Respiratory Disease Research Center, تهران, ايران , Mohammadi, Forozan shahid beheshti university of medical sciences - NRITLD, Masih Daneshvari Hospital - Department of Clinical Anatomical Pathology, تهران, ايران , Keynama, Kaveh shahid beheshti university of medical sciences - NRITLD, Masih Daneshvari Hospital - Department of Pulmonary Medicine, تهران, ايران , Rahmani, Laleh shahid beheshti university of medical sciences - NRITLD, Masih Daneshvari Hospital - Department of Pulmonary Medicine, تهران, ايران , Masjedi, Mohammad Reza shahid beheshti university of medical sciences - NRITLD, Masih Daneshvari Hospital - Department of Pulmonary Medicine, تهران, ايران
Abstract :
Background: Lung cancer remains the leading cause of cancer-related deaths in the world. In Iran, lung cancer is the fifth leading cancer and its prevalence rate has been increasing steadily. In this study, the clinicopathological aspects of lung cancer are discussed. Materials and Methods: Between October 2002 and November 2005, 242 (178 men, 64 women) patients with histologically confirmed lung cancer were interviewed according to a questionnaire. Results: Women developed the disease at an earlier age than men (55.9±14.2 versus 61.3±12.3 years; p=0.004); 66.5% of lung cancer patients (85.4% of men and 14.1% of women) were smokers (p 0.0001); 76.3% of participants, who had exposure to secondhand smoke, were females. Among the environmental carcinogens, the most exposures were to inorganic dusts (49.8%) and chemical compounds (34.9%).Most male and female patients suffered from adenocarcinoma (28.9%) and non small cell carcinoma (28.5%). The prevalence of adenocarcinoma was higher in the non-smoker group, whereas incidence of squamous cell carcinoma and small cell carcinoma was higher among smokers (p 0.0001). In this study, most patients (74.0%) presented with an advanced-stage tumor (IIIB or IV). Conclusion: Our results suggest that in addition to cigarette smoking, other environmental, occupational and socioeconomic factors may play a role in the development of lung cancer.
