Letters to the Editor: Further expanding possibilities of successful stem cell transplantation in coronary artery disease/An alternative approach of stem cell delivery to myocardium: combined usage of antegrade coronary arterial infusion and retrograde venous obstruction

Dear Editor, We read with great interest the manuscript entitled “An alternative approach of stem cell delivery to myocardium: combined usage of antegrade coronary arterial infusion and retrograde venous” by Nisancı et al. (1), in which they showed advantages of cardiac venous occlusion during intraarterial injection of stem cells. Stem cell therapy has recently attracted attention of cardiologists investigating methods of replacement of the damaged myocardium and recreation of autonomously functioning cardiomyocytes. Despite obvious advances in purification of stem cells and their delivery to the site of myocardial affection, there are still many unresolved issues related to transportation, implantation and differentiation of stem cells (2, 3). Success of the therapy is primarily subjected to the cellular environment and intercellular cooperation at the site of myocardial affection.