Title of article :
Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives
Author/Authors :
al-tamimi, entesar o. university of baghdad - college of science - department of chemistry, Iraq , muslih, raad m. university of baghdad - college of science for women - department of chemistry, iraq , thejeel, khalida a. university of al-mustansria - college of pharmacy - department of pharmaceutical chemistry, iraq
Abstract :
New series of Schiff bases 2(a-j) and corresponding beta-lactam derivatives 3(a-j) were synthesized from cefalexin (1) as starting material. The compound (1) was reacted with different aldehydes and ketones to give Schiff bases derivatives 2(a-j). The synthesized Schiff bases were cyclized by chloroacetyl chloride in the presence of triethylamine to form beta-lactam derivatives 3(a-j). The compounds were characterized by deremination melting point, FT-IR and 1H NMR. The beta-lactam derivatives were screened in vitro antibacterial against some bacterial species.
Keywords :
cefalexin , Schiff base , Beta , lactam , Antibacterial activity
Journal title :
Baghdad Science Journal
Journal title :
Baghdad Science Journal
