Author/Authors :
Hacıoğlu, Yalçın Harbor UCLA Medical Center and the Los Angeles Biomedical Research Institute, USA , Gupta, Mohit Harbor UCLA Medical Center and the Los Angeles Biomedical Research Institute, USA , Choi, Tae-Young Harbor UCLA Medical Center and the Los Angeles Biomedical Research Institute, USA , George, Richard T. Johns Hopkins University - School of Medicine, USA , Deible, Christopher R. University of Pittsburgh - School of Medicine, USA , Jacobson, Lisa P. Johns Hopkins Bloomberg School of Public Health, USA , Witt, Mallory D. Harbor UCLA Medical Center and the Los Angeles Biomedical Research Institute, USA , Palella, Frank J. Northwestern University - School of Medicine, USA , Post, Wendy S. Johns Hopkins University - School of Medicine, Johns Hopkins Bloomberg School of Public Health, USA , Budoff, Matthew J. Los Angeles Biomedical Research Institute, USA , Budoff, Matthew J. Harbor UCLA Medical Center, USA
Abstract :
Objective: The methodology for use of cardiac CT angiography (CTA) in low risk populations is not well defined. In order to present a reference for future studies, we present CTA methodology that is being used in an epidemiology study- the Multicenter AIDS Cohort Study (MACS). Methods: The Multicenter AIDS Cohort Study (MACS) is an on-going multicenter prospective, observational cohort study. The MACS Cardiovascular Disease substudy plans to enroll 800 men (n= 575 HIV seropositive and n=225 HIV seronegative) age 40-70 years for coronary atherosclerosis imaging using cardiac CTA. The protocol includes heart rate (HR) optimization with beta blockers; use of proper field of view; scan length limitation; prospective ECG-gating using the lowest beam voltage possible. All scans are evaluated for presence, extent, and composition of coronary atherosclerosis, left atrial volumes, left ventricular volume and mass and non-coronary cardiac pathology. Results: The first 498 participants had an average radiation dose of 2.5±1.6 milliSieverts (mSv) for the cardiac CTA study. Overall quality of scans was fair to excellent in 98.6% of studies. There were three significant adverse events-two allergic reactions to contrast and one subcutaneous contrast extravasation. Conclusion: Cardiac CTA was safe and afforded a low effective radiation exposure to these asymptomatic research participants and provides valuable cardiovascular endpoints for scientific analysis. The cardiac CTA methodology described here may serve as a reference for use in future epidemiology studies aiming to assess coronary atherosclerosis and cardiac anatomy in low risk populations while minimizing radiation exposure.
