The role of vitamin E in reducing of cadmium blood toxicity in mice

The present study was designed to investigate the role of vitamin E to eliminate the toxic effect of cadmium on blood parameters . A total ot 24 healthy mice, were randomly located into one of the following groups: - First group was injected with 0.1 ml. olive oil intraperontal and left as a control group The second group was exposed to 4 mg/kg body weight cadmium in the form of CdCl2 via intraperitoneal injection (ip) daily for ten days The third group was injected (ip) with 4 mg/kg cadmium daily for ten days, and then the animals were injected (ip) with 0.6 IU (24 IU/kg body weight) vitamin (E) daily for two weeks. Blood samples for hematological analysis were taken by cardiac puncture at the ten days and twenty four days from the beginning of the experimental work. The result revealed to significant reduction in red blood cells, packed cell volume and hemoglobin values of second group compared with the control group. In addition to a significant elevation in total white blood cells, acidophil, monocytes, and lymphocytes. Neutrophils declined significantly due to the exposure of cadmium .No basophiles were seen in the three studied groups. The results also indicated that vitamin.( E ) was capable to get all the abnormal values of blood parameters to its normal values as with control group.