THE EFFECT OF SNAKE VENOM METALLOPROTEINASE/DISINTEGRIN LIKE ACTIVITY ON LIVER OF ALBINO WHITE MICE

This is a study on the effect of snake venom metalloproteinase/ Disintegrin like action (SVMP) purified from Cerastes cerastes venom on expression of TNF-alpha, and Heme-oxygenase-1 in white mice liver tissue injected intraperitoneally with the purified fraction. Hepato-protective effect of the fraction against some hepatotoxins as CCI4 was investigated histo-pathologically.This hepato-protection coincides with expression of TNF-alpha and HO-1 genes in liver tissue .This study is supported by grant no. 28 from Professor Dr. M. F. EL-Asmar