Title of article :
Head and neck cancer association to CIAP-2 expression due to human papillomavirus-16 (HPV-16) infection
Author/Authors :
Mansour, Amal Ain Shams University - Faculty of Medicine - Medical Biochemistry Department, Egypt , Helmy, Hussein Ain Shams University - Faculty of Medicine - Otolaryngology Department, Egypt , Ali, Marwa Ain Shams University - Faculty of Medicine - Medical Biochemistry Department, Egypt , Kassim, Samar Ain Shams University - Faculty of Medicine - Medical Biochemistry Department, Egypt
Abstract :
It was relevant to assess the impact of a HPV-16 (human papillomavirus-16) which is a high-risk genotype on head and neck cancers and its relation to CIAP-2 expression (Cellular Inhibitor of apoptosis-2). Tissue samples were taken from patients diagnosed as head and neck cancer. All samples were subjected to qualitative polymerase chain reaction (PCR) analysis for HPV, qualitative and semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) of CIAP-2. There was a significant association between HPV-16 CIAP2 positivity and head and neck tumors. CIAP-2 expression in malignant tissues was highly associated with HPV-16 infection at sensitivity 73.9 % and absolute specificity
Keywords :
Papillomavirus , HPV , 16 , Rt , PCR , CIAP , 2
Journal title :
The Egyptian Journal of Biochemistry and Molecular Biology
Journal title :
The Egyptian Journal of Biochemistry and Molecular Biology
