Author/Authors :
Elsayed, Ghada M Cairo University - National Cancer Institute - Clinical Pathology Department, Egypt , Hafez, Mohamad M Cairo University - National Cancer Institute - Virology and Immunology Unit, Egypt , Nassar, Hanan R Cairo University - National Cancer Institute - Medical Oncology Department, Egypt , Mabrok, Yasser Cairo University - National Cancer Institute - Biochemistry Unit, Cancer Biology Bepartment, Egypt , Moneer, Manar Cairo University - National Cancer Institute - Epidemiology and Medical Statistics Department, Egypt
Abstract :
Purpose: DCC (Deleted in colorectal carcinoma) is a tumor suppressor gene located on chromosome band 18q21. Loss of DCC expression has been detected in 80% of colorectal carcinoma and many other types of tumor. Expression of the DCC has been found to be lost in some patients with acute myeloid leukemia (AML). Although this finding is critical to leukemogenesis, its prognostic significance remains unclear. This study was done to evaluate vloss of DCC expression in AML and its prognostic significance. Exverimental design: A group of 27 previously untreated patients with adult AML presenting to the outpatient clinic of Medical Oncology Department, National Cancer Institute, Cairo University were evaluated in addition to 5 healthy volunteers. DCC gene expression in AML cells was determined by RT-PCR. Results: Loss of DCC expression was detected in 20 patients (74.1%). The complete remission rate was 9/27 (33.3%). And most of patients with negative DCC expression 14/20(70%) were resistant to induction chemotherapy compared to 6/20(30%) who entered into complete remission. Test of significance couldn t be done due to small number of groups compared. The cumulative overall survival for patients with normal DCC expression (positive) was 43% compared to 40% for patients with negative DCC expression with no significant difference between the two groups (p=0.613). Conclusion: These findings suggest that, as for colorectal tumors, inactivation of DCC can have a role in the development of AML and it might serve as a potential marker to improve risk assessment in adult AML.
