Author/Authors :
Alblewi, Bushra University of Dammam and King Fahd Hospital of the University - College of Medicine - Dermatology Department, Saudi Arabia , Bukhari, Iqbal A. University of Dammam and King Fahd Hospital of the University - College of Medicine - Department of Dermatology, Saudi Arabia , Hasan, Manal University of Dammam and King Fahd Hospital of the University - College of Medicine - Internal Medicine Department, Saudi Arabia , Alzahani, Abdulaziz University of Dammam and King Fahd Hospital of the University - College of Medicine - Dermatology Department, Saudi Arabia , Bukhari, Raed University of Dammam and King Fahd Hospital of the University - College of Medicine - Internal Medicine Department, Saudi Arabia , Bashawri, Layla University of Dammam and King Fahd Hospital of the University - College of Medicine - Pathology Department, Saudi Arabia , Al Shawarby, Muhammad University of Dammam and King Fahd Hospital of the University - College of Medicine - Pathology Department, Saudi Arabia
Abstract :
Hemophagocytic syndrome (HPS) is characterized by the activation of histiocytes with prominent hemophagocytosis in bone marrow and other reticuloendothelial systems. It has two forms: primary and secondary. The precise pathogenesis of HPS is unclear but a dysregulation of macrophage–lymphocyte interactions with subsequent increases in the levels of both T-cell-derived and macrophagederived cytokines has been suggested. Cardinal symptoms of HPS are prolonged high fever, hepatosplenomegaly, cytopenias, lymphadenopathy and neurological symptoms. In this report, we present a case Systemic Lupus Erythematosus associated with HPS and acute pancreatitis.
