Title of article :
Dual Modality of 18 F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography in Patients with Cervical Carcinoma of Unknown Primary
Author/Authors :
Freudenberg, Lutz S. University Hospital Essen - Clinic of Nuclear Medicine, Germany , Fischer, Markus University Hospital Essen - Department of Otorhinolaryngology, Germany , Antoch, Gerald University Hospital Essen - Department of Diagnostic and Interventional Radiology, Germany , Jentzen, Walter University Hospital Essen - Clinic of Nuclear Medicine, Germany , Gutzeit, Andreas University Hospital Essen - Department of Diagnostic and Interventional Radiology, Germany , Rosenbaum, Sandra J. University Hospital Essen - Clinic of Nuclear Medicine, Germany , Bockisch, Andreas University Hospital Essen - Clinic of Nuclear Medicine, Germany , Egelhof, Thomas University Hospital Essen - Department of Diagnostic and Interventional Radiology, Germany
From page :
155
To page :
160
Abstract :
Objective: To evaluate an optimized F-18-fl urodeoxyglucose-positron emission tomography/ computed tomography (FDG-PET/CT) acquisition protocol for head and neck cancer and assess the usefulness of combined FDG-PET/CT in locating unknown primary tumors in patients with biopsy-proven cervical lymph node metastases. Subjects and Methods: Twenty-one patients with cervical lymph node metastases of unknown primary tumors underwent staging with FDG-PET/CT. The images of FDG-PET alone, CT alone, FDG-PET/CT read side by side and fused and FDG-PET/CT were evaluated separately by 2 physicians. Imaging results were correlated with either histology (n = 14) or clinical follow-up (n = 7). Results: On the fused FDG-PET/CT images, primary tumors were identified in 12 patients (57%); with FDG-PET alone and FDG-PET and CT read side by side 11 (52%) primary tumors were found while CT alone identified 5 (23%) pri- mary tumors. Conclusion: Our data indicate that fused FDG-PET and CT images increased the sensitivity of detecting carcinoma of unknown primary (CUP) tumors compared to CT alone, but not to FDG-PET alone or FDG-PET and CT read side by side. Hence accurate fusion of functional and morphologic data by FDG-PET/CT is a promising imaging modality in the clinical workup of patients with cervical CUP tumors.
Keywords :
Unknown primary tumor , Positron emission tomography , computed tomography , Fluorodeoxyglucose , Dual modality
Journal title :
Medical Principles and Practice
Journal title :
Medical Principles and Practice
Record number :
2694369
Link To Document :
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