Author/Authors :
Hsieh, Ming-Chia Department of Internal Medicine, Taiwan , Hsieh, Ming-Chia Graduate Institute of Medical Genetics, Taiwan , Chen, Chung-Chi Graduate Institute of Medicine, Taiwan , Wang, Jaw-Yuan Kaohsiung Medical University - Department of Surgery, Taiwan , Chong, Inn-Wen Department of Internal Medicine, Taiwan , Yhe, Chi-Jung Municipal Hsiao-Kang Hospital, Taiwan , Shin, Shyi-Jang Department of Internal Medicine, Taiwan , Lin, Shiu-Ru Kaohsiung Medical University - Department of Surgery, Taiwan
Abstract :
Objective: To investigate the association between family history of cardiovascular disease (CVD) and cholesteryl ester transfer protein (CETP) TaqIB polymorphism in Taiwanese subjects. Subjects and Methods: In this cross-sectional study, 240 subjects (115 men and 125 women) were divided into two groups based on whether or not they had a parental history of CVD. Polymerase chain reaction/restriction fragment length polymorphism was used to analyze the genotype of the subjects for the TaqIB polymorphism of CETP in intron 1. Results: The frequency of the B1B1 genotype was significantly higher in Taiwanese subjects with a family history of CVD than in those without it (31.2 vs. 18.8%, odds ratio = 1.97, 95% confidence interval = 1.084–3.579, p = 0.035). Siblings with the B1B1 genotype had lower levels of serum high-density lipoprotein cholesterol (HDL-C) than siblings with either B1B2 (46.7 ± 11.0 vs. 52.5 ± 11.1 mg/dl, p = 0.034) or B2B2 genotypes (46.7 ± 11.0 vs. 55.2 ± 9.6 mg/dl, p = 0.01). Conclusion: CETP TaqIB polymorphism is associated with plasma HDL-C levels. The CETP B1B1 genotype may influence the susceptibility to CVD in Taiwan.
Keywords :
Cholesteryl ester transfer protein TaqIB polymorphism , Cholesteryl ester transfer protein B1B1 genotype , Cardiovascular disease , family history
