Author/Authors :
Celec, Peter Comenius University - Faculty of Medicine, Faculty of Natural Sciences - Department of Molecular Biology, Slovakia , Burska, Stella Midland Regional Hospital, Ireland , Sebekova, Katarina Slovak Health University - Institute of Preventive and Clinical Medicine, Slovakia , Kalousova, Marta Charles University - Faculty of Medicine, Institute of Clinical Biochemistry and Laboratory Diagnostics, Czech Republic , Zima, Tomas Charles University - Faculty of Medicine, Institute of Clinical Biochemistry and Laboratory Diagnostics, Czech Republic , Murin, Jan Faculty Hospital - Department of Internal Medicine, Slovakia
Abstract :
Objective: The aim of this study was to analyse the dynamics of advanced glycation end products (AGEs) after acute myocardial infarction (MI). Subjects and Methods: Blood samples were taken from 20 non-diabetic patients with acute MI on the 1st, 2nd, 3rd and 5th day after the onset of symptoms. Serum AGE levels were estimated spectrofluorometrically. Results: A marked decrease in the AGE-specific fluorescence was observed, especially between the 1st and the 2nd days after MI. Conclusion: The findings of this study tend to contradict the suggestion that AGEs are relatively stable markers of carbonyl stress. Although the reason for this is currently unknown, this observation may have implications for ongoing studies of AGEs in cardiovascular diseases.
