Author/Authors :
Caamaño, José Universidad de La Frontera - Facultad de Medicina - Laboratorio de Biología Molecular y Farmacogenética, Departamento de Ciencias Básicas, Departamento de Medicina Interna, Chile , Saavedra, Nicolás Universidad de La Frontera - Facultad de Medicina - Laboratorio de Biología Molecular and Farmacogenética, Departamento de Ciencias Básicas, Chile , Saavedra, Nicolás Núcleo de Desarrollo Científico-Tecnológico en Biorecursos (BIOREN), Chile , Jaramillo, Priscilla C. Universidad de La Frontera - Núcleo de Desarrollo Científico-Tecnológico en Biorecursos (BIOREN) - Laboratorio de Biología Molecular y Farmacogenética, Departamento de Ciencias Básicas, Chile , Lanas, Cecilia Universidad de La Frontera - Facultad de Medicina - Departamento de Medicina Interna, Chile , Lanas, Fernando Universidad de La Frontera - Facultad de Medicina, Núcleo de Desarrollo Científico-Tecnológico en Biorecursos (BIOREN) - Departamento de Medicina Interna, Chile , Salazar, Luis A. Universidad de La Frontera - Núcleo de Desarrollo Científico-Tecnológico en Biorecursos (BIOREN) - Laboratorio de Biología Molecular y Farmacogenética, Departamento de Ciencias Básicas, Chile
Abstract :
Objective: To investigate the possible association between the codon 72 polymorphism (Pro72Arg, rs1042522) of the tumor suppressor gene (TP53) and the presence of coronary artery disease (CAD) in Chilean subjects. Subjects andMethods: A total of 209 unrelated patients with a diagnosis of CAD confirmed by angiography (33–74 years old) and 216 healthy controls (30–68 years old) were included in this study. The Pro72Arg polymorphism of the TP53 gene was evaluated by PCR-RFLP. Results: The genotype distribution for the Pro72Arg variant of the TP53 gene in CAD patients (PP: n = 13, 6.2%; PR: n = 61, 29.4%; RR: n = 135, 64.6%) and controls (PP: n = 18, 8.3%; PR: n = 94, 43.5%; RR: n = 104, 48.1%) was significantly different (p = 0.003). Similarly, the allelic frequency was also different (p = 0.003). The odds ratio for CAD related to the 72Arg allele was 2.0 (95% CI = 1.33–2.90), confirming the presence of an association. Conclusion: These findings suggest that the Pro72Arg polymorphism of the TP53 gene is associated with CAD in Chilean individuals.
