Title of article :
Case Report: Concomitant Drug- and Infection-Induced Antineutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis with Multispecific ANCA
Author/Authors :
Kontic, Milica , Radovanovic, Sanja University of Belgrade - Faculty of Medicine, Clinics of Pulmonology, Dermatology and Allergy and Clinical Immunology, Clinical Center of Serbia, Serbia , Nikolic, Milos University of Belgrade - Faculty of Medicine, Clinics of Pulmonology, Dermatology and Allergy and Clinical Immunology, Clinical Center of Serbia, Serbia , Bonaci-Nikolic, Branka University of Belgrade - Faculty of Medicine, Clinics of Pulmonology, Dermatology and Allergy and Clinical Immunology, Clinical Center of Serbia, Serbia
Abstract :
Objective: To report the first case of concomitant drug- and infection-induced antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) in a patient treated with propylthiouracil (PTU) and suffering from tuberculosis. Presentation and Intervention: A 28-year-old woman with PTU-treated hyperthyroidism presented with fever, purpura, pulmonary cavitations and ANCA to myeloperoxidase, bactericidal/permeability-increasing protein (BPI), proteinase-3 and elastase. Skin histopathology confirmed vasculitis. However, sputum examination revealed Mycobacterium tuberculosis. Remission was achieved after PTU withdrawal and treatment with antituberculosis drugs. Conclusion: Our case confirmed that BPI-ANCA are elevated in active tuberculosis. Multispecific ANCA were helpful for the diagnosis of concomitant PTU- and M. tuberculosis-induced AAV.
Keywords :
Antineutrophil cytoplasmic autoantibodies , Tuberculosis , Propylthiouracil , Drug , induced vasculitis , Bactericidal , permeability , increasing protein
Journal title :
Medical Principles and Practice
Journal title :
Medical Principles and Practice
