Author/Authors :
Zakaria, Z.A. Universiti Putra Malaysia - Faculty of Medicine and Health Sciences - Department of Biomedical Science, Malaysia , Abdul Hisam, E.E. Universiti Teknologi MARA - Faculty of Pharmacy, Puncak Alam Campus - Department of Pharmaceutical Science, Malaysia , Norhafizah, M. Universiti Putra Malaysia - Faculty of Medicine and Health Sciences - Department of Pathology, Malaysia , Rofiee, M.S. Universiti Teknologi MARA - Faculty of Pharmacy, Puncak Alam Campus - Department of Pharmaceutical Sciences, Malaysia , Othman, F. Universiti Putra Malaysia - Faculty of Medicine and Health Sciences - Department of Biomedical Science, Malaysia , Hasiah, A.H. Universiti Putra Malaysia - Faculty of Medicine and Health Sciences - Department of Biomedical Science, Malaysia , Hasiah, A.H. Universiti Teknologi MARA - Faculty of Pharmacy, Puncak Alam Campus - Department of Pharmaceutical Sciences, Malaysia , Vasudevan, M. Universiti Teknologi MARA - Faculty of Pharmacy, Puncak Alam Campus - Department of Pharmaceutical Sciences, Malaysia
Abstract :
Objective: The aim of the present study was to determine the anti-ulcer activity of a methanol extract of Bauhinia purpurea leaf (MEBP). Materials and Methods: MEBP was administered at doses of 100, 500 and 1,000 mg/kg and its effects on acute toxicity, absolute ethanol- and indomethacin-induced gastric ulceration, and pyloric ligation tests in rats were investigated. Results: At a dose of 5,000 mg/kg, MEBP did not cause any signs of toxicity in rats when given orally. Oral administration of MEBP exerted anti-ulcer activity (p 0.05) in all models tested. However, a dose-dependent protection was observed only in the indomethacin-induced gastric ulceration model. Histological studies supported the observed anti-ulcer activity of MEBP. In the pyloric ligation assay, MEBP significantly increased gastric wall mucus secretion (p 0.05), but did not affect the acidity of the gastric contents. Conclusion: MEBP exhibited anti-ulcer activity, which could be due to the presence of flavonoids, saponins or other polyphenols, thereby validating the traditional use of B. purpurea in the treatment of ulcers.
Keywords :
Bauhinia purpurea , Methanol extract , Anti , ulcer activity , Flavonoids , Saponins , Polyphenols
