Title of article :
A Newborn with Teratogenic Effect of Imatinib Mesylate: A Very Rare Case Report
Author/Authors :
Jain, Namita J.C.D. Dental College, India , Sharma, Deepak Fernandez Hospital - Department of Neonatology, India , Agrawal, Renu S.P. Medical College - Department of Pediatrics, India , Jain, Adeesh S.P. Medical College - Department of Pediatrics, India
Abstract :
Objective: To report a case of teratogenic effect of imatinib mesylate (IM) in a newborn, whose mother was suffering from chronic myelogenous leukemia and was treated with IM for 4 years, including during her pregnancy. Case Presentation and Intervention: The newborn was diagnosed with microtia of the right ear, preauricular tag on the left side, absence of right depressor angular oris muscle, and imperforate anus. Infantogram showed dextrocardia, hemivertebrae in the thoracic region and cervical spina bifida occulta. The newborn was operated on for the imperforate anus and was discharged in good condition. Conclusion: This case revealed that IM is not safe for the fetus and leads to teratogenicity. Hence, we recommend that pregnant women should not be treated with IM.
Keywords :
Chronic myeloid leukemia · Imatinib mesylate · Teratogen · Congenital malformations · Newborn · Pregnancy · Tyrosine kinase inhibitors
Journal title :
Medical Principles and Practice
Journal title :
Medical Principles and Practice
