Title of article :
Arq ajwain protects nonalcoholic fatty liver disease on high-fat diet-induced obese rat
Author/Authors :
Haque ، Md Rafiul School of Pharmacy - Al-Karim University , Ahmad ، Md Afroz Department of Pharmacology - Integral University , Ashraf ، Kamran Faculty of Pharmacy - University Teknologi MARA (UITM), Kampus Puncak Alam , Akhter ، Md Habban School of Pharmaceutical and population Health information (SoPPHI) - DIT University , Jameel ، Mohammad Regional Research Institute of Unani Medicine (RRIUM) - Central Council for Research in Unani Medicine (CCRUM) , Ali ، Abuzer Department of Pharmacognosy - College of Pharmacy - Taif University , Akhtar ، Wasim School of Pharmacy - Al-Karim University , Dhaka ، Monika School of Pharmaceutical and population Health information (SoPPHI) - DIT University , Rana ، Kavita Noida Institute of Engineering and Technology (Pharmacy Institute)
Abstract :
In the present study, we investigated the safety and therapeutic efficacy of arq ajwain (AA) against nonalcoholic fatty liver disease (NAFLD) on a high-fat diet (HFD) induced obese rat model. After 4 weeks of the treatment, AA (4 mL/kg, twice a day) and AA1 (7.75 mL/kg, twice a day) treatments reduced body weight, serum triglycerides (TG), total cholesterol (TG), glucose, insulin, leptin, pancreatic lipase activity and alanine aminotransferase (ALT) levels (p 0.001). AA, AA1, and thymol (T) treatments also decreased lipids (TG and TC) levels and increased thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and catalase (CAT) levels in hepatic tissue (p 0.001). Moreover, treatment groups considerably reduced hepatic inflammation, steatosis, hepatocellular ballooning, and fibrosis. These results recommend that arq ajwain has a strong protective effect against NAFLD in HFD induced obese rat models.
Keywords :
Ajwain , insulin , Leptin , Nonalcoholic fatty liver disease , Oxidative stress
Journal title :
Trends In Phytochemical Research
Journal title :
Trends In Phytochemical Research
