Title of article :
Synthesis and Biological Activities of Some New Derivatives Based on 5-Styryl-2-amino-1,3,4-thiadiazole
Author/Authors :
Narran ، Shetha Fadhil Department of Chemistry - College of Science for women - University of Baghdad , Mohammed ، Suad Salman Department of Chemistry - College of Science for women - University of Baghdad , Omer ، Maab Khattab Department of Chemistry - College of Science for women - University of Baghdad , Hussein ، Iftikhar Ahmed Department of Chemistry - College of Science for women - University of Baghdad , Jawad ، Noor Mohammed Department of Chemistry - College of Science for women - University of Baghdad , Shweish ، Batool Karim Department of Chemistry - College of Science for women - University of Baghdad
Abstract :
In this research, 5-Styryli-2-amino-1, 3, 4-thiadiazole [C1] was prepared from the reaction of acid 3-phenyl propenoic acid with thiosemicarbazide. Amic acids [C2-C5] were synthesized by reactive compound [C1] with different types of hydrides, then [C2, C4] were treated with AC2O in the presence of NaOAC as a catalyst giving Imide compounds [C6, C7]. The structure of the new derivatives was confirmed via FT-IR spectroscopy, some of which were confirmed via 1H-NMR spectroscopy. Three of these new derivatives were evaluated by their Esherichiacoli, Staphylococcus, and Rhizopus emporium.
Keywords :
1 , 3 , 4 , Thiadiazle , Amic acid , Imide , Anti , bacterial , Anti , fungal
Journal title :
Chemical Methodologies
Journal title :
Chemical Methodologies
