Title of article
Design and synthesis of some novel 2-(3-methyl-2- oxoquinoxalin-1(2H)-yl)-N-(4-(substituted)phenyl) acetamide derivatives for biological evaluation as anticonvulsant agents
Author/Authors
Ibrahim, Mohamed-Kamal Al-Azhar University - Faculty of Pharmacy - Pharmaceutical Chemistry Department, Egypt , Abd-Elrahman, Ashraf A. Al-Azhar University - Faculty of Pharmacy - Pharmaceutical Chemistry Department, Egypt , Ayyad, Rezk R.A. Al-Azhar University - Faculty of Pharmacy - Pharmaceutical Chemistry Department, Egypt , El-Adl, Khaled Al-Azhar University - Faculty of Pharmacy - Pharmaceutical Chemistry Department, Egypt , Mansour, Ahmed M. Al-Azhar University - Faculty of Pharmacy - Pharmacology and Toxicology Department, Egypt , Eissa, Ibrahim H. Al-Azhar University - Faculty of Pharmacy - Pharmaceutical Chemistry Department, Egypt
From page
101
To page
111
Abstract
A new series of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)-N-(4-substitutedphenyl)acetamides (2–15a–c) were designed and synthesized in order to evaluate their anticonvulsant activity. The structure of the synthesized compounds was confirmed by elemental analysis and spectral data (IR, 1H NMR and Mass). The data obtained from biological screening revealed that; compounds 9c and 8c showed the highest anticonvulsant activities in experimental mice.
Keywords
2 , (3 , Methyl , 2 , oxoquinoxalin , 1(2H) , yl)acetamide , Quinoxaline , Acetamide , Anticonvulsant agent
Journal title
Bulletin Of Faculty Of Pharmacy, Cairo University
Journal title
Bulletin Of Faculty Of Pharmacy, Cairo University
Record number
2696752
Link To Document