Title of article :
Sagitol C, a new cytotoxic pyridoacridine alkaloid from the sponge Oceanapia sp.
Author/Authors :
Ibrahim, Sabrin R.M. Assiut University - Faculty of Pharmacy - Department of Pharmacognosy, Egypt , Mohamed, Gamal A. Al-Azhar University - Faculty of Pharmacy - Department of Pharmacognosy, Egypt , Elkhayat, Ehab S. Al-Azhar University - Faculty of Pharmacy - Department of Pharmacognosy, Egypt , Fouad, Mostafa A. Minia University - Faculty of Pharmacy - Department of Pharmacognosy, Egypt , Proksch, Peter Heinrich-Heine-Universitat Dusseldorf - Institut fur Pharmazeutische Biologie und Biotechnologie, Germany
Abstract :
A new pyridoacridine alkaloid named sagitol C (2) together with two known compounds; kuanoniamine C (1) and sagitol (3) were isolated from the EtOAc fraction of the Indonesian sponge Oceanapia sp. Their chemical structures were established on the basis of physical and spectroscopic methods 1D and 2D NMR, in addition to mass spectrometry and comparison with literature data. Sagitol C was found to exhibit cytotoxic activity when tested against different cancer cell lines.
Keywords :
Oceanapia , Pyridoacridine alkaloid , Sagitol C , Cytotoxicity
Journal title :
Bulletin Of Faculty Of Pharmacy, Cairo University
Journal title :
Bulletin Of Faculty Of Pharmacy, Cairo University
