Title of article :
Synthesis and anti-mycobacterial evaluation of some new isonicotinylhydrazide analogues
Author/Authors :
Elhakeem, Maha A. Cairo University - Faculty of Pharmacy - Pharmaceutical Organic Chemistry Department, Egypt , Taher, Azza T. Cairo University - Faculty of Pharmacy - Pharmaceutical Organic Chemistry Department, Egypt , Abuel-Maaty, Suzan M. Cairo University - Faculty of Pharmacy - Pharmaceutical Organic Chemistry Department, Egypt
Abstract :
The synthesis of some new 3,4-disubstituted thiazolylideneisonicotinohydrazide derivatives 3a–k, 2-substituted thiazolidinylisonicotinamide derivatives 4a–d and pyrrolylisonicotinamide derivatives 5, 6 and 7 is described. The resulted compounds are evaluated for their in vitro antitubercular activity. The minimum inhibitory concentration (MIC) of compound 3g showed comparable in vitro activity to isoniazid against Mycobacterium tuberculosis H37Ra 7131 strain in concentration 9.77 μg/mL.
Keywords :
Isoniazid derivatives , Synthesis , Antitubercular activity
Journal title :
Bulletin Of Faculty Of Pharmacy, Cairo University
Journal title :
Bulletin Of Faculty Of Pharmacy, Cairo University
