Synthesis of some new 5-substituted-2-((6-chloro- 3,4-methylenedioxyphenyl)methylthio)-1,3,4- oxadiazole derivatives as suitable antibacterial inhibitors

Heterocyclic molecules belong to the most attractive group owing to their broad spectrum of antimicrobial activities. In the undertaken research, a number of new 5-substituted-2-((6-chloro-3,4-methylenedioxyphenyl)methylthio)-1,3,4-Oxadiazole derivatives (6a–l) were synthesized by converting various aryl/aralkyl carboxylic acids (1a–l) into corresponding esters (2a–l), carbohydrazides (3a–l) and 5-substituted-1,3,4-Oxadiazol-2-thiols (4a–l). The last step included the synthesis of target molecules, 6a–l, by stirring 4a–l and 6-chloro-3,4-methylenedioxybenzyl chloride (5) in a polar aprotic solvent. The structures of all the synthesized molecules were corroborated through spectral analysis. The screening of these molecules against antibacterial activity rendered them moderate inhibitors and most likely against Escherichia coli, relative to the reference standard, ciprofloxacin.