Title of article
SYNTHESIS OF SUBSTITUTED DIHYDROPYRIMIDINES AS HYPOTENSIVE AGENTS
Author/Authors
Abdel-Aziz, Salah A. Al-Azhar University - Faculty of Pharmacy - Department of Pharmaceutical Medicinal Chemistry, Egypt , El-Koussi, Nawal A. Assiut University - Faculty of Pharmacy - Department of Medicinal Chemistry, Egypt , Hassan, Hoda Y. Assiut University - Faculty of Pharmacy - Department of Medicinal Chemistry, Egypt , Youssef, Adel F. Assiut University - Faculty of Pharmacy - Department of Medicinal Chemistry, Egypt , Yousri, Magda M. Assiut University - Faculty of Medicine - Department of Pharmacology, Egypt
From page
159
To page
179
Abstract
A series of Dihydropyrimidines (DHPMs) with variable substituents at four positions in pyrimidine nucleus (I-IV), were prepared and tested for their calcium channel blocker and hypotensive effect using amlodipine as a reference compound. Molecular alignment revealed a direct correlation between fitting and in-vitro rat ileum relaxation. A pharmacophore was developed for compounds with hypotensive and/or calcium channel blocking activity. Series IV showed hypotensive and calcium antagonist effect, while series I and II showed calcium antagonist activity without hypotensive action. Series III were devoid of either effect.
Journal title
Bulletin Of Pharmaceutical Sciences, Assiut University
Journal title
Bulletin Of Pharmaceutical Sciences, Assiut University
Record number
2696893
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