Author/Authors :
El-Kader, Adel M. Abd Al-Azhar University - Faculty of Pharmacy - Department of Pharmacognosy, Egypt , Nafady, Alaa M. Al-Azhar University - Faculty of Pharmacy, - Department of Pharmacognosy, Egypt , Ahmed, Amany S. Assiut University - Faculty of Pharmacy - Department of Pharmacognosy, Egypt , Ibraheim, Zedan Z. Assiut University - Faculty of Pharmacy - Department of Pharmacognosy, Egypt
Abstract :
The methanolic extract of Polygonum bellardii All. (flowering aerial parts) and its fractions in addition to the isolated compounds (1-6) showed significant antioxidant potential by DPPH^• scavenging activity technique. It also showed hepatoprotective activity against carbon tetrachloride (CCl4) induced hepatic injury in albino rats. The fractions exhibited antibacterial activity against both Gram positive and Gram negative bacteria in addition to antifungal activity. The total methanolic extract of Polygonum bellardii All. did not show signs of toxicity and mortality up to 4 g/kg dose. Determination of total flavonoid content with respect to quercetin spectrophotometrically indicated the presence of 185.2±1.03 mg/g dried extract.
