Title of article :
A REVIEW ON HYDROXYAPATITE-BASED SCAFFOLDS AS A POTENTIAL BONE GRAFT SUBSTITUTE FOR BONE TISSUE ENGINEERING APPLICATIONS
Author/Authors :
Krishnamurithy, G University of Liverpool - Institute of Translational Medicine, Faculty of Health and Life Sciences - Musculoskeletal Science Research Group, Department of Molecular and Clinical Cancer Medicine, UK , Krishnamurithy, G university of malaya - National Orthopaedic Centre for Research and Learning (NOCERAL), Faculty of Medicine - Tissue Engineering Group (TEG), Department of Orthopaedic Surgery, Malaysia
Abstract :
The biocompatibility and similarity of hydroxyapatite (HA) to the mineral composition of the bone has made HA a potential candidate in bone tissue engineering (BTE). Over the past few decades, its application as bone graft in combination with stem cells has gained much importance. The use of bone marrow-derived mesenchymal stromal cells (MSCs) will enhance the rate and quality of defect repair. However, application of hydroxyapatite as a material to develop a 3-dimension scaffold or carrier to support MSCs in vitro is still in its infant stage. This review will discuss the source, manufacturing methods and advantages of using HA scaffolds in bone tissue engineering applications.
Keywords :
hydroxyapatite , mesenchymal stem cell , porosity , sintering
Journal title :
Journal Of Health and Translational Medicine
Journal title :
Journal Of Health and Translational Medicine
