Title of article :
9 Department of Gastroenterology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
Author/Authors :
Ejtehadi, Fardad Gastroenterohepatology Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Pashaei, Mohammad Reza Department of Gastroenterology - Urmia University of Medical Sciences, Urmia, Iran , Shamsaeefar, Alireza Shiraz Organ Transplant Center - Shiraz University of Medical Sciences, Shiraz, Iran , Motazedian, Nasrin Shiraz Transplant Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Sivandzadeh, Gholam Reza Gastroenterohepatology Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Niknam, Ramin Gastroenterohepatology Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Malekhosseini, Ali Shiraz Organ Transplant Center - Shiraz University of Medical Sciences, Shiraz, Iran , Lankarni, Kamran B Health Policy Research Center - Institute of Health - Shiraz University of Medical Sciences, Shiraz, Iran
Abstract :
This study investigated the safety and efficacy of tenofovir disoproxil fumarate (TDF) compared with lamivudine (LAM) in the prevention of recurrent HBV infection after liver transplantation (LT).This study investigated the safety and efficacy of tenofovir disoproxil fumarate (TDF) compared with lamivudine (LAM) in the prevention of recurrent HBV infection after liver transplantation (LT).A total of 302 HBV-related post-transplant patients who received liver transplants from deceased donors were enrolled in this retrospective study from 2011 to 2015 in the Shiraz Organ Transplant Center, Iran. The demographic data, kidney function, recurrence, resistance rate, and acute rejections at 1-, 6-, and 12-month intervals and after 12 months were compared on TDF (n=209) and lamivudine (n=93) groupsDuring a median follow-up period of 42.9 months, mean creatinine level was not significantly different between the two groups. Hepatitis B virus recurrence rate as well as acute graft rejection episode had no statistical difference in either group over the study period.
Conclusion: Kidney function, creatinine level, disease recurrence, and acute graft rejection were comparable between tenofovir disoproxil fumarate and lamivudine in patients who received follow-up periods.
